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KMID : 0617219960070010073
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Duksung Bulletin Phamaceutical Sciences
1996 Volume.7 No. 1 p.73 ~ p.87
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The Effect of Chrysantemum indica L. on carbon tetrachloride
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Abstract
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The effect of Chrysantemum indica on CCl_4-induced hepatotoxicity was investigated. We examined the effect of methanol extract of Chrysantemum indica by biochemical analysis and histopathologic examination. ALT and AST levels were decreased by 5.1% and 1.3% in pretreatment group of Chrysantemum indica compared to CCl_4 control group respectively. There were significant changes neither in the level of total protein, albumin, alkaline phosphate, triglyceride and cholesterol nor in BUN and creatinine. In histopathologic examination, there were severe necrosis and hemorrhage with infiltration of inflammatory cells around the central vein, zone 3 of the liver with CCl_4 treated rat.
Ballooning degeneration of hepatocytes were frequently noted in the periphery where the hemorrhagic necrosis. In Chrysantemum indica pretreatment group, we observed mild degree of ballooning degeneration and inflammatory cell infiltration. No gross necrosis was observed. We measured malondialdehyde(MDA) formation by thiobabituric acid method. It was shown that the formation of MDA in Chrysantemum indica pretreatment group was decreased compared to the CCl_4 control group. We got the result of the effect of Chrysantemum indica oon CCl_4-induced hepatotoxicity by decreasing serum ALT and AST. It seems that the decrease of lipid peroxidation is related to the recovery effect.
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